Post Doctoral Research Officer - Bioinformatics & Cellular Genomics (Melbourne)

Employer: St Vincent's Institute (SVI)

Closing date: 3 Feb 2019

Brief position description: 

The Facility

St Vincent’s Institute (SVI) www.svi.edu.au is an internationally recognised independent research organization, based on the St Vincent’s Hospital Campus on the edge of Melbourne’s CBD. The Institute has a dedicated team of over 150 talented research staff and students, who are committed to improving the health and life-expectancy of Australians. We focus on common diseases that represent major health issues for Australians today, including diabetes, bone diseases, cancer, cardiovascular disease, obesity and Alzheimer’s disease. 

The Laboratory 

The Bioinformatics & Cellular Genomics Laboratory is a newly funded group at SVI, established to solve the challenges of analysing and interpreting the large-scale biological data generated from medical research activity. In a jointly funded arrangement between SVI and the Melbourne Integrative Genomics Group (part of Melbourne University School of Mathematics and Statistics) and under the direction of NHMRC Fellow and Oxford graduate Dr Davis McCarthy, the Bioinformatics & Cellular Genomics Laboratory is capable of using large-scale studies of DNA and single-cell genetics to drive future medical discoveries. 

The Position 

We are seeking a motivated and successful postdoctoral Researcher to manage an independent project in single-cell genetics, developing new computational methods and open-source software to enable cloud-scale analyses of single-cell data. You will implement statistical and machine learning approaches and coordinate the processing and analysis of ‘omic data, identifying opportunities to customise more efficient workflows and methods where warranted. The position also plays an important role in the overall performance and scientific activities of the laboratory as you will contribute to publications, assist in the supervision of students and present at seminars and lab meetings. The researcher will also have an organisation-wide responsibility in collaborating closely with the researchers of the wet-lab laboratories, providing computational expertise on experimental design and data analysis. 

The successful incumbent will have a PhD (or equivalent) in a computational discipline relevant to bioinformatics and cellular genomics (bioinformatics, statistics, machine learning, computer science, applied mathematics, physics or similar) and possess advanced skills in using computer programming and scripting in R or Python and, ideally, familiarity with one or more of C++, Go, Nim, Rust, Java, Perl or SQL programming languages. You will have a demonstrated ability in the use of Unix-based systems, computing clusters and related queueing systems and in large-scale data analysis and management. Ideally you will have prior experience working in high-performance computing environments, including academic and/or commercial cloud computing platforms and experience using bioinformatics workflow management software (e.g. Snakemake, Nextflow, CWL). Your track record in bioinformatics, genomics, computational biology or other relevant quantitative fields will be evidenced by high-quality publications. Demonstrated experience developing open-source software and reproducible data analyses will be highly regarded. 

Salary - commensurate with qualifications and experience, $83,000 - $90,000 pa plus:

• 9.5% superannuation
• generous $15,900 FBT exempt salary packaging

Position Description - see job website listing below

Applications - via Seek please. Include current CV, covering letter addressing selection criteria, based on Position Description

Enquiries - Dr Davis McCarthy dmccarthy@svi.edu.au

Job website: https://www.svi.edu.au/careers_students/careers/current_vacancies/

Contact name: Helen Ritchie

Contact email: hritchie@svi.edu.au



 PhD Position (with Stipend), NSW

Opportunity: PhD Position (with Stipend)

Research Topic: The Epigenomics of Multiple Sclerosis

Closing date: 22/02/2019

Brief Outline:This project will involve analysis of genome-wide methylation data sets in relation to Multiple Sclerosis (MS) outcomes. Given the large amount of data involved and the complex computational and statistical models to be applied, this project will be heavily focused on data analysis including the use of novel approaches.

Detailed Description:MS is a common autoimmune disorder that can lead to severe neurological symptoms like such as reduced cognitive function, psychiatric problems and physical disabilities. The disease is complex, arising from the complex interplay of genetic factors and environmental exposures. A major goal in MS research is to understand these gene-environment interactions and to use this information to personalise treatments to improve patient outcomes. Epigenetics is the study of DNA-based factors that can influence gene expression independently of underlying DNA sequence and can be modified by environmental exposures (eg, medicines). As such, epigenetics provides a natural interface for the environment to interact with the genome to influence disease onset, severity and progression. DNA methylation is an one epigenetic mechanism that can now be measured on a genome-wide scale (ie. epigenomics) and has given rise to the epigenome-wide association study (EWAS) design. The MS group at the Hunter Medical Research Institute have been performing MS EWASs for a number of years and have identified a number of exciting findings. Thanks to some newly awarded funding we are now continuing this line of investigation in an effort to identify epigenetic factors that influence MS onset, severity and progression This project will involve analysis of MS EWAS data sets currently being generated using the Illumina Epic Arrays. Given the large amount of data involved and the complex computational and statistical models to be applied, this project will be heavily focused on data analysis. Specifically, the project will involve using a number of different bioinformatics approaches to address the specific research questions. These include identifying differentially methylated regions with programs like MINFI, cellular deconvolution of methylation signal using custom algorithms, estimation of epigenetic aging using DNAage, and application of machine learning to build predictive models (eg. GLMNet).

Eligibility Criteria: The applicant will have an aptitude and interest in fields including data science, bioinformatics, computational genomics and statistical genetics. A basic knowledge and skills in using linux operating systems, biostatistical methods and R programming to analyse data sets is required. Good written and oral communication skills and the ability to work independently are desirable. The successful applicant will need to be accepted as a PhD student with either UoN or QUT and will receive a scholarship stipend of $27 082 per annum, tax free, indexed annually for 3.5 years. International students may be required to pay university (tuition) fees.

Contact:  For more information on the project and application process please contact Assoc. Professor Rodney Lea (rodney.a.lea@gmail.com) before Jan 29th, 2019.

Post-doc in Bioinformatics/Computational Biology, Adelaide

Position title: RESEARCH OFFICER/POSTDOCTORAL FELLOW IN BIOINFORMATICS/COMPUTATIONAL BIOLOGY

Employer: South Australian Health & Medical Research Institute

Closing date: Feb 8 2019

Brief position description: The Lynn EMBL Australia Group at the South Australian Health and Medical Research Institute (SAHMRI) in Adelaide, Australia is now seeking applications for a bioinformatics/computational biology researcher to work on a variety of projects in the cancer systems biology and systems immunology areas. Prior experience in at least some of the following areas is essential: analysis of next generation sequencing (NGS) data; network and pathway biology; cancer systems biology; machine learning methods and experience in biomarker discovery and validation. Active collaboration and the ability to manage multiple difference projects simultaneously is essential. An initial 2 year full-time contract is available, potentially renewable. 

Please see https://www.sahmriresearch.org/human-resources/careers/218 for a position description and to apply.

Job website: http://www.sahmriresearch.org/human-resources/careers/218

Contact name: David Lynn

Contact email: david.lynn@sahmri.com

(Sent via Australian Bioinformatics And Computational Biology Society)

Bioinformatician - Pathogen Genomics, NSW

Position title: Bioinformatician - Pathogen Genomics

Employer: NSW Health Pathology

Closing date: 16/12/2018

Brief position description: This position is based at the Public Health Pathogen Genomics Laboratory, Centre for Infectious Disease and Microbiology Laboratory Services, NSWHP-ICPMR at Westmead and plays a key role in the delivery of NSW state-wide pathogen genomics services. The Pathogen genomics bioinformatician is responsible for: 
Lead and manage genome sequencing projects as directed by relevant supervising pathologists and laboratory management from initiation to implementation including the review and evaluation of systems and processes to ensure effectiveness of service delivery. Support reliable and secure collection, storage and archival of genomic data and relevant metadata in accordance with national and international regulations and guidelines. Develop, implement and maintain genomic data QC and analysis pipelines. Organise, coordinate and deliver training in microbial bioinformatics for relevant laboratory staff and other peers.

Refer to the URL for more details.

Job website: http://iworkfor.nsw.gov.au/job/bioinformatician-pathogen-genomics-136518

Contact name: Prof. Vitali Sintchenko

Contact email: Vitali.Sintchenko@health.nsw.gov.au

Two Bioinformatics/Genome analyst positions in South Australia

Employer: Centre of Cancer Biology, an Alliance between the University of South Australia and SA Pathology

Closing date: 9am Thursday November 29

Brief position description: The Centre for Cancer Biology in Adelaide is advertising two bioinformatics/genome analyst positions within the Molecular Pathology/Lymphatic Development/Bioinformatics groups. The positions will involve analysis and interpretation of RNASeq, ChIPSeq, ATACSeq, HiC, WES and WGS data. Further information is available from Hamish Scott (hamish.scott@sa.gov.au), Natasha Harvey (natasha.harvey@unisa.edu.au)
or Andreas Schreiber (andreas.schreiber@sa.gov.au).

Job website: https://workingatunisa.nga.net.au/cp/index.cfm?event=jobs.checkJobDetailsNewApplication&returnToEvent=jobs.listJobs&jobid=0B2C3592-40A4-BA78-C358-A4A55C37DA9A&CurATC=External&CurBID=62AFB35D-9273-4A11-8DCC-9DB401354197&JobListID=22fc4f47-e994-46a3-b8c9-9bc901269f43&jobsListKey=382f5055-dc54-4de6-ab3d-0677eb4185c5&persistVariables=CurATC,CurBID,JobListID,jobsListKey,JobID&lid=57152020078

Contact name: Andreas Schreiber

Contact email: andreas.schreiber@sa.gov.au



Associate Research Fellow in Bioinformatics at Deakin University

Position title: Associate Research Fellow in Bioinformatics

Employer: Deakin University

Closing date: 18/11/2018

Brief position description: SALARY RANGE: $67,562 to $90,827 pa (plus 17% super)
EMPLOYMENT TYPE: Full-time and fixed term for 2 years
LOCATION: Geelong Waurn Ponds Campus
FURTHER INFORMATION: Previous applicants need not apply

ABOUT THE ROLE

The Associate Research Fellow will initiate and conduct research in the area of Bioinformatics. The position will be part of the Bioinformatics Core Unit at Deakin University. In this role you will be involved in computer programming, systems administration, web page management and bioinformatics analysis.

This will include:

Initiating and conducting research under limited supervision either as a member of a team, or independently, to achieve the objectives of the Deakin University Core Bioinformatics unit.
Contributing to building an active national research record, preparing findings for oral and written communication including publications and the generation of external research income.
Effectively producing data, maintaining data protocols and entering data into the appropriate internal and public databases. Conduct preliminary data cleaning, screening and analysis.
Constructively contributing to a vibrant research team, including participating with colleagues in developing and maintaining links and partnerships with industry and the wider community.

ABOUT YOU 

Honours or higher level degree (PhD) in bioinformatics or computer science with a substantial research component.
Demonstrated skills in the coordination of data collection, data entry and analysis for high throughput sequencing technologies.
Experience in working with computer based data acquisition and analysis systems.
Proficiency with Java programming and/or web page development.
For a full list of the selection criteria please see the position description

CONTACT FOR FURTHER INFORMATION: Associate Professor Tamsyn Crowley, Email: tamsyn.crowley@deakin.edu.au

CLOSING DATE: Sunday 18 November 2018

Job website: http://jobs.deakin.edu.au/psc/HCMP/EMPLOYEE/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?FOCUS=Applicant&SiteId=1&_ga=2.199518574.1704097410.1540162040-1093997198.1532864010&

Contact name: Tamsyn Crowley

Contact email: tamsyn.crowley@deakin.edu.au


Postdoctoral Research Fellow (Single Cell Transcriptomics). Singapore

Position title: Postdoctoral Research Fellow (Single Cell Transcriptomics)

Employer: Singapore Immunology Network (ASTAR, Singapore)

Closing date: 10/12/2018

Brief position description: Note: 3 positions available

A Bioinformatician research fellow (postdoctoral) position is available in Dr Jinmiao Chen’s Single-Cell Computational Immunology (SCCI) lab. The position will perform single-cell RNA-seq data analysis and derive knowledge from the data by applying state-of-the-art tools or developing novel computational methods. The analytical scope may include data pre-processing, quality control to remove low quality cells, normalization/batch effect correction, dimensionality reduction, clustering analysis, automatic cell type identification, cell lineage and pseuedotime inference, cell-to-cell interactions, integration of heterogeneous datasets and data types, building human single-cell atlas, and etc. The work will involve a wide range of exciting and cutting-edge research projects including human cancer immunology (ex Leukemia, Gasstric Cancer, Lung Cancer, etc), infectious diseases (ex TB, Dengue, HIV, HBV, etc), autoimmune diseases (ex SLE, psoriasis, atopic dermatitis, etc), and fundamental research to understand immune system (ex. heterogeneity, origins and functions of dendritic cells, macrophages, T cells, B cells and etc). Where existing computational methods are not adequate to handle the data, the candidate will have the opportunity to develop novel methods under the PI’s supervision and with help from other lab members. The lab is currently focusing on developing Single-Cell Big Data & Artificial Intelligence framework and several AI analytical tools under development are to be released in near future. The candidate will have the opportunity to work in a collaborative environment, interact with excellent scientists from multiple disciplines, and grow rapidly in both biological and computational knowledge and skills. The position will have the opportunity to publish first-authored and co-authored papers in high-impact journals and international conferences, as well as patent publication and potential commercialization of the tools to be developed. In addition, the candidate will have the opportunity to work with MNC pharmaceutical companies via industrial collaborations

Job website:

Contact name: Jinmiao Chen

Contact email: chen_jinmiao@immunol.a-star.edu.sg

Bioinformatician position in Sydney

Position title: Bioinformatician

Employer: The Sydney Head and Neck Cancer Institute (SHNCI) at the Chris O’Brien Lifehouse

Closing date: 31st October 2018

Brief position description: The Sydney Head and Neck Cancer Institute (SHNCI) at the Chris O’Brien Lifehouse aims to integrate both basic and clinical research to develop preventive strategies, improve cure rate, and enhance the quality of life of patients with head and neck cancer. A major aspect of our research programme is focused on understanding the role of genes and molecular and cellular processes in the development and progression of head and neck cancers.
The opportunity:
We are now seeking Bioinformatics Research Officer for a position based between the core SHNCI research team and our collaborators at the Charles Perkins Center, University of Sydney. This can be negotiated as a part time (minimum 0.6FTE) or a full time position. The position will be based at the Charles Perkins Center, University of Sydney. The successful candidate will have the opportunity to work with both DNA and RNA sequencing data. There are multiple opportunities to work with whole genome, transcriptome and targeted panel sequencing outputs of a variety of head and neck malignancies including skin, mucosal and salivary gland tumours. The candidate will be supervised jointly by Prof Jean Yang and Dr. Kitty Lo and will be reporting directly to Professor Jonathan Clark, Associate Professor Ruta Gupta and Dr Bruce Ashford.
Essential duties:
• Working/developing research grade head and neck cancer genomic analysis pipelines
• Work within a team environment to undertake translational research in head and neck cancer with an emphasis on developing biological insights that are relevant to patient outcome.
• Staying abreast on advances in genomics and/or next generation sequencing technology in general, maintaining knowledge on precision medicine
• Develop and maintain software packages of developed methods as well as maintenance of related webpages.
• Day-to-day support and training of PhD students as required.
• Input into manuscript design, development and editing of studies based on sequencing data analysis.
This position is a key role within our highly collaborative multidisciplinary research team. The successful candidate will be responsible for curating and analysing large volumes of genomic data from our ongoing research effort, and thereby contribute to advancing our translational research programme.
Selection Criteria:
1. A minimum of a Bachelor’s degree in bioinformatics or a related area of science
2. Highly developed skills in bioinformatics and genomics. In particular, experience with low level processing or performing initial data analysis on recent platforms of omics data such as next generation sequencing (essential).
3. Superior computer programming or software development skills, a preference in R but not essential.
4. Demonstrated understanding of the incorporation into University life of the principles of Equal Employment Opportunity and Affirmative Action; and ability to work positively with staff and students from a diverse range of backgrounds
5. Experience working with clinical research or medicine is desirable, but not essential
6. Good communication skills (both written and oral).
7. Ability and willingness to assist others within the team.
Apply by sending your cover letter and resume to careers@lh.org.au
To find out more, please contact Dr Aniko Huizer-Pajkos on 0285140365 or aniko.huizer-pajkos@lh.org.au
Applications close: 19th October 2018

Job website: http://www.seek.com.au/job/37413569?_ga=2.78607517.803453506.1538962444-1878375570.1517369122

Contact name: Aniko Huizer-Pajkos

Contact email: aniko.huizer-pajkos@lh.org.au

PhD scholarships (Bioinformatics) at the University of Hong Kong

Employer: The University of Hong Kong

Closing date: 15 November 2018

Brief position description: The Ho Laboratory at the School of Biomedical Sciences of the University of Hong Kong (https://holab-hku.github.io/) focuses on the use of bioinformatics and systems biology approaches to tackle longstanding problems in basic and transnational medicine. Most projects in this laboratory involve integrative analysis next-generation sequencing (NGS) data such as single-cell RNA-seq, ChIP-seq, and whole genome sequencing data. Some research areas include:

- Scalable algorithm for single cell RNA-seq analysis
- 3D virtual reality visualisation of biological data
- Wearable devices, physical activity and heart rate dynamics
- Causal disease mutation identification in whole genome sequencing data
- A cloud-based approach for incorporating scalability into genome informatics
- Integrative metagenomics analysis

We are seeking outstanding PhD students to join our laboratory. Very strong candidates are eligible to apply for a prestigious Hong Kong PhD Fellowship, which will provide a tax-free scholarship of HKD$301,200 (AUD$54,460) per year. The fellowship also provides a travel allowance of HKD$12,600 (AUD$2,280) per year for the duration of the candidature. 

Qualifications:
- Bachelor degree in a quantitative discipline (bioinformatics computer science, statistics, mathematics, physics, engineering, etc), with first class honours or equivalent. 
- Proficient in at least one programming / scripting language (R, python, perl, C, C++, Java, etc)
- Familiarity with the Unix operating system
- Prior experience in bioinformatics is desirable

Eligible candidates may also be considered for employment as a research assistant or postdoctoral fellow (for PhD holders).

Job website: http://www.sbms.hku.hk/staff/joshua-wing-kei-ho

Contact name: Joshua Ho

Contact email: jwkho@hku.hk

Senior Research Fellow / Associate Professor (Bioinformatics), UNSW

Employer: UNSW

Closing date: 11pm on Sunday 21st October 2018.

Brief position description: We are seeking an exceptional Senior Lecturer or Associate Professor to deliver outstanding research in bioinformatics and integrative genomics with a focus in cancer research. The successful candidate will be based within the Adult Cancer Program of the Prince of Wales Clinical School at the Lowy Cancer Research Centre, UNSW Sydney.

Job website: http://external-careers.jobs.unsw.edu.au/cw/en/job/494839/senior-research-fellow-associate-professor-bioinformatics

Contact name: Ian Jones

Contact email: i.jones@unsw.edu.au